Overnight Use of Reverge Geometry CLs Increases Inflammatory Mediators

"Continuous long-term overnight use of reverse geometry lenses results in a significantly increased presence of inflammatory mediators compared with wearing 30-night silicone-hydrogel (Si-H) contact lenses or wearing no lenses, show study results," reports News-Medical. "Specifically, interleukin (IL)-6 and IL-8, and matrix metalloproteinase-9 (MMP-9) were significantly increased after 12 months use of the corneal refractive therapy (CRT; reverse geometry) lenses, which induce temporary flattening in the central corneal curvature, compared with use of the other lens type or no lenses." Read more.